Having fled the corporate armed forces of Cygnat Owari through the bowels of Southeast Asia, young Daisy and her synthetic protector Itto find refuge in the last place anyone would dare look for them: Ground Zero. Once a bustling suburb of Taipei, the haunted walls of Sungshan, Taiwan are now scorched with the images of the War Spore's first victims. And it is here amongst the ghosts that the Warrior and child find a moment of Peace. As Itto takes stock of their situation, he analyzes the new directives that have merged so completely with his original programming -- a mysterious bundle of code known only as "Bushido." But this moment of peace proves to be as fleeting as summer snow...

Lone Wolf 2100 continues the saga inspired by Kazuo Koike and Goseki Kojima's seminal manga series Lone Wolf and Cub.